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[2] McDaniel, D

Recent research indicates that Metformin can penetrate the blood-brain barrier (BBB) and enter brain tissues [13]

Although peripheral and central enterostatin administration decreases dietary fat intake in animals (while enterostatin-receptor antagonists did the opposite) (186), its administration to humans has shown no effects on food intake, appetite, energy expenditure, or body weight (187)

Abbreviations AD : Alzheimer disease ALS : Amyotrophic lateral sclerosis Aps : Spontaneous action potentials CA1 : Cornu ammonis 1 CA3 : Cornu ammonis 3 CCK-8 : Cell counting Kit-8 assay ChIP : Chromatin immunoprecipitation assay CKO : Conditional knockout DCFH-DA : Fluorescent probe 2,7-Dichlorodi-hydrofluorescein diacetate DEGs : Differentially expressed genes DFX : Deferoxamine DG : Dentate gyrus EEG : Electroencephalogram recordings ELISA : Enzyme-linked immunosorbent assay GFAP : Glial fibrillary acidic protein GSDMD : Gasdermin D IC : 50 The half maximal inhibitory concentration LPS : Lipopolysaccharide MMP : Mitochondrial membrane potential N2a : The mouse neuroblastoma neuro-2a cells NeuN : Neuronal nuclei NLRP3 : NOD-like receptor family pyrin domain containing 3 OCT : Optimum cutting temperature compound PD : Parkinson's disease PILO : Pilocarpine p-STAT3 : Phosphorylated signal transducer and activator of transcription 3 PTZ : Pentylenetetrazole pY 705 -STAT3 : STAT3 Tyr705 phosphorylation qRT-PCR : Real-time quantitative reverse transcription PCR ROS : Reactive oxygen species SE : Status epilepticus siRNA : Small interfering RNA STAT3 : Signal transducer and activator of transcription 3 TLC : Thin-layer chromatography TPEN : The membrane-permeable Zn 2+ chelator TRM : Tremor rat TRPM7 : Transient receptor potential melastatin 7 TRPM7-CKO : TRPM7 conditional knockout TSQ : The N-(6-methoxy-8-quinolyl)-para-toluenesulfonamide TTM : Tetrathiomolybdate SK : Small conductance Ca 2+ -activated K + References Shi J, Gao W, Shao F

Clin Chem Lab Med 2024